Endocrine Abstracts

It has long been known that the AR is regulated not only by its cognate steroid hormone, but also by interactions with a constellation of co-regulatory and signaling molecules. Checkpoint kinase 2 (CHK2) is a serine/threonine protein kinase whose main function is regulating the DNA damage response (DDR) triggered by double-strand DNA breaks. The androgen receptor (AR) is a major driver of prostate cancer, even at the castration–resistant stage of the disease. Our research...